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Introduction: The purpose of the current case is to give a detail description on an incidence of a traumatized upper left central incisor with symptomatic periapical periodontitis which was root treated. Descriptions: The apical portion of the tooth had a large apical lesion with external root resorption that end up with an open apex due to the loss of tooth cementum, dentine and adjacent hard tissue. The tooth was endodontically retreated, and the apical region was treated surgically with apical curettage and retrograde Mineral Trioxide Aggregate filling (MTA). Result(s): The affected tooth was considered successful both functionally and aesthetically during a 12-month follow-up. Conclusion(s): Apicoectomy and retrograde filling with MTA is a viable option in case of treating traumatized tooth with large peri-apical lesion and open apex.Copyright © 2023 Japan University of Health Sciences & Japan International Cultural Exchange Foundation.
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BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccinations have been administered worldwide, with occasional reports of associated neurological complications. Specifically, the impact of vaccinations on individuals with X-linked Charcot-Marie-Tooth disease type 1 (CMTX1) is unclear. Patients with CMTX1 can have stroke-like episodes with posterior reversible encephalopathy syndrome on magnetic resonance imaging (MRI), although this is rare. CASE SUMMARY: A 39-year-old man was admitted with episodic aphasia and dysphagia for 2 d. He received SARS-CoV-2 vaccination 39 d before admission. Physical examination showed pes cavus and reduced tendon reflexes. Brain MRI showed bilateral, symmetrical, restricted diffusion with T2 hyperintensities in the cerebral hemispheres. Nerve conduction studies revealed peripheral nerve damage. He was diagnosed with Charcot-Marie-Tooth disease, and a hemizygous mutation in the GJB1 gene on the X chromosome, known to be pathogenic for CMTX1, was identified. Initially, we suspected transient ischemic attack or demyelinating leukoencephalopathy. We initiated treatment with antithrombotic therapy and immunotherapy. At 1.5 mo after discharge, brain MRI showed complete resolution of lesions, with no recurrence. CONCLUSION: SARS-CoV-2 vaccination could be a predisposing factor for CMTX1 and trigger a sudden presentation.
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Monitoring of side effects after coronavirus disease 2019 (COVID-19) vaccination has become an important issue for health systems worldwide to ensure its safety. Recently cases of deep vein thrombosis (DVT), vaccine-induced immune thrombotic thrombocytopenia, and autoimmune hepatitis have been described: the underlying pathophysiological mechanisms are still debated. We report on a patient who presented with DVT and acute hepatitis 8 days after receiving the first dose of the ChAdOx1 nCoV-19 adenoviral vector vaccine against COVID-19. The patient is a 56-year-old male who was already affected by a rare form of axonal Charcot-Marie-Tooth disease linked to MME (membrane metalloendopeptidase) gene variation and associated with mild symptoms. His blood exams did not have any evidence of thrombocytopenia but D-dimer, troponin T, alanine transaminase, and aspartate aminotransferase were abnormal, suggesting the presence of a blood clot and acute hepatitis. The patient was treated with subcutaneous enoxaparin for 15 days and with rivaroxaban for the following 8 months: his symptoms improved and his exams showed recanalization of the veins and a healed liver. The pathogenesis of thrombosis and hepatitis after vaccination is still unclear, especially in subjects affected by rare comorbidities and this may affect the safety of vaccination in this type of population. We highlight the importance of careful monitoring of side effects after vaccination: clinical suspicion must rise when patients complain of symptoms that differ from their usual presentation.
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This study has systematically investigated the types of drug delivery in the treatment and prevention of oral and dental and cardiorespiratory diseases in patients and animals involved in the disease. Early recognition of risk factors and primary prevention significantly reduces complications and mortality in chronic heart diseases. Lifestyle modification with diet, exercise and smoking cessation is very important to reduce cardiovascular risk factors. In the first days of the disease, when the patient has mild symptoms and has not yet developed respiratory symptoms, you can start treatment with painkillers for headache, sore throat and body pain, along with taking antitussive medicine and vitamin D and C although scientifically the effect of vitamin C. It is not proven, but considering that we still do not have extensive studies on this disease, it seems that taking vitamins may help the patient. Sometimes, some patients themselves start treatment with azithromycin, while this antibiotic has an effect on antibacterial infections and has no effect on the disease of Covid-19. Favipiravir treatment should be started in high-risk outpatients with corona. Of course, along with treatment with favipiravir and similar antiviral effects, it can be effective in the treatment of corona. Famotidine and melatonin, which help improve sleep and are said to have antiviral effects. Of course, melatonin medicine should be taken at around 11 to 12 at night. Because it affects the sleep and wake cycle. Montelukast along with fexofenadine, can have antiviral effects for covid-19 patients. Since the beginning of the Corona pandemic, the world has emphasized on the monthly consumption of vitamin D, but if you do not have a monthly intake, use 1000 milligrams daily or up to 50 thousand units every week and after some time continue to consume vitamin D on a monthly basis. It is also recommended to take vitamin C and magnesium, and it is better for patients to eat foods rich in protein, potassium, and dairy products.
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This systematic review of scientific sources (190 articles) shows that the simultaneous presence of cardio-metabolic, dental, as well as neurologic diseases is common in people who are hospitalized due to COVID-19 infection, and cardiovascular complications occur frequently. Many people with COVID-19 have few or no symptoms. However, COVID-19 can make the blood "sticky," blocking both small (capillaries) and large blood vessels, which may cause 1 heart attacks, strokes, or blood clots in the legs or lungs. People with diabetes, high blood pressure, or pre-existing heart problems are at higher risk of developing such complications if they get COVID-19. A total of 190 studies reported relevant information. Further studies were conducted in China and the United States of America. The results show that high blood pressure, diabetes and heart disease are very common in hospitalized patients with COVID-19 and are associated with an increased risk of mortality. More than a third of patients with COVID-19 had a history of high blood pressure, 23.4% of them mentioned a previous heart or blood vessel problem, 30.4% had diabetes, and 14.6% were obese.
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This study has done a systematic review of drug therapy and assessment of the occurrence of dental and neurological problems in patients affected by covid-19. There are various reasons that can cause an infection in the tooth. One of the most common causes of tooth infection is root canal treatments you have had in the past. Unfortunately, bacteria grow in this area and can lead to infection. Having an infection in the tooth can be very dangerous. Because it may spread to other parts of the body and cause serious problems. For this reason, it is very important to recognize the symptoms of infection. When a crack or cavity is formed on the tooth, if not treated in time, an infection may occur in the tooth. Because these are the gates that can pave the way for bacteria to enter your teeth. The most common type of disease is accompanied by episodes of severe pain that may be felt in the eyes, ears, lips, nose, forehead, cheeks, teeth or jaws, or anywhere on the face. The similarity of the symptoms of this complication with the symptoms of common dental diseases is a factor in misdiagnosis. This can lead to a series of unnecessary dental treatments that not only won't solve the problem, but may actually make it worse. Some patients undergo dental treatment at least once before the diagnosis of the disease. 1.
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This study investigated dental problems and radiological and cardiac evaluations in patients affected by Covid-19. Heart disease is related to the health of the teeth, and people who have damaged and decayed teeth are more prone to cardiovascular disease. Researchers have concluded that poor dental hygiene is a sign of acute heart disease risks. In the report presented by Tarje Imna service, a group of researchers examined almost 65 thousand people infected with the corona virus in order to evaluate the effects of the covid 19 virus on the oral and dental health of the affected people. According to the results of this research, one of the effects of the corona virus on the body is the reduction of oral moisture. Almost 43% of patients accepted this effect. In general, dry mouth is one of the causes of oral and dental diseases, especially bad breath. Corona virus also increases the risk of tooth decay by reducing the moisture in the mouth. Another effect of the corona virus on the mouth and teeth is to cause ulcers in the gums and tongue. Of course, in this case, researchers do not comment with certainty, because they believe that other factors are also effective in causing these wounds. Some experts say that considering that more than 47 percent of adults who are 30 years old or older have periodontal diseases, such as gum infection, inflammation of the gums and bone around the teeth. We should expect that the existing dental and oral problems will become more acute in case of infection with Covid-19.
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The proceedings contain 294 papers. The topics discussed include: impact of the genotype and phenotype of CYP3A and P-GP on the apixaban and rivaroxaban blood concentrations in real-world setting;direct oral anticoagulant-related bleeding in atrial fibrillation patients alters DNA methylation of NOS3 and KDR genes;impact of obesity on dexamethasone pharmacokinetic in COVID-19 hospitalized patients: an observational exploratory study;intestinal permeability in transplant patients: are systemic short-chain fatty acids an early biomarker?;immunogenicity 5-months after homologous or heterologous booster vaccination in health care workers primed with Ad26.COV2.S;geographic variation in top-10 prescribed medication and potentially inappropriate prescription in Portugal: an ecological study of 2.2 million older adults;quantitative proteomics of hepatic drug-metabolizing enzymes and transporters in patients with colorectal cancer liver metastasis;pharmacological characterization of a novel lipid-rich breast cancer patient-derived xenograft;and multiple sclerosis drugs and dental and gingival disorders: an observational retrospective study and disproportionality analysis in the world pharmacovigilance database.
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Background Patients are hesitant to enter a dental hospital because of the significant danger of cross infection and illness transmission due to rapid spread of corona virus. Objective To assess knowledge regarding Covid-19, oral health practices and circumstances on dental treatment during a pandemic. Method Cross sectional study was conducted among patients visiting dental department of Dhulikhel hospital from September to October 2020. Questionnaires were interviewed following safety protocols regarding the pandemic and descriptive analysis was performed. Both verbal and written consent as well as ethical approval was taken before the study. Result A total 411 patients aged 14 to 75 years old from 14 different districts across Nepal participated in the study. All of the patient were free of Covid-19 symptoms and had strong knowledge and awareness about disease transmission. During the crisis 96% of the people maintain good oral hygiene while 25.8% acquire new dental problems where majority experienced oral discomfort and swelling, 93.2% of them did not attend a dental clinic or hospital in the interim owing to fear and inaccessibility. Majority of the participants were impressed by the safety precautions and preparations during treatment and 99.3% strongly suggest or pledge to visit dental department if necessary during the pandemic. Conclusion Dental patient visiting Dhulikhel hospital is highly aware of current health crisis, possible transmission and preventive measures. Proper safe hospital setup can encourage them to seek dental treatment during crisis. Dental pain and swelling in Endodontic department recorded most common dental emergency during this pandemic.
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Inserted a big size of rubber ear phone cover into the nose is a rare case.Foreign body regarding children is common and need to be seriously considered.Nowadays, using an earphone for music players and games isverycommon among children that need to be more cautious.In general practitioner’s practice, several limitations seen with no fully equipped and emergency trolley, no general anaesthetic set up and no X ray. In this case report, we reported a 10-year-old child with bad smelling breath for 2 years with on and off pain and difficulty in breathing. It has become worsened until the child informshis mother regarding this incidence last weeks. Last 2 weeks, the child was examined in dental clinic for this bad smelling breath and no dental problem identify. The parents were refused to bring the child to the hospital because of this Covid-19 situation worsening in this state currently. They decided to cometo nearby general practitioner where the smelly and soaked with pus in this ear was removed without any complication in that clinic without any anaesthesia using blunt crocodile forceps.
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Keywords: Placement expansion;TECS placement;3:1 model Purpose: The trust was awarded funding from HEE to increase physiotherapy placement capacity throughout this academic year. Aims of our project included: • Improve student experience and provide them with vital skills for future delivery of healthcare. • Improve educator experience. • Enable students to experience rehabilitation during/post pandemic (patients with long term conditions and those that had suffered an acute event). • Improve patient experience. When the COVID-19 pandemic began we put in place new service models that would continue to support the rehabilitation needs of patients. We implemented a new service delivery model in CR, which included remote service delivery using telephones, videos and platforms such as AccuRx. The CR Service agreed to trial an increase in student numbers from one to three per placement. This was made possible by having access these digital platforms. Methods: At the start of the project we completed educator engagement sessions to identify barriers to increasing student numbers and then discussed solutions to could overcome this. Alongside this we explored gaps in capacity and changes happening in service delivery due to COVID-19 to identify areas that we could explore expanding placement offers in. Including the following for CR: • Alternative placement models, in particular the 3:1 placement model and the Technology Enabled Care Service placement model. • Utilising digital platforms available to make placements both face-to-face and virtual. • Enabling students to access medical records, assessments and the electronic paperwork that is required to ensure that they have all of the same opportunities that they would have had if their placement had be face-to-face. Results: We are currently still collating data however this project will be completed by the end of this academic year. [RL1] [OP2] The data that we are collecting includes: surveys on student and educator experiences, PDSA cycles post placements and the % increase in the number of placements offered. Delivering the placements virtually allowed for students to work remotely, ensuring that social distancing could still be maintained in office spaces with the increase in student numbers. Conclusion(s): In spite of recent studies reporting that 49.3% of CR programmes were suspended due to COVID-19, we successfully adapted our CR service delivery. By the using a 3:1 model and embracing digital platforms the CR service increased placement capacity. There have been some inevitable teething problems due to the use of digital platforms, however after overcoming these, placements have run smoothly and there has been a sustained increase in placement capacity. Impact: Results of this project are transferrable to other CR Services and to similar outpatient services and will facilitate an expansion of offers for other clinical placements. This will assure an expansion in student numbers for the HEIs and enable more students to complete placements to prevent delays in qualification. These placements give the students vital skills for the delivery of future health care and enable them to experience the patient rehabilitation pathway during a pandemic. Furthermore, this project allowed the service to have an increased workforce which helped reduce waiting times, improving the patient experience. Funding acknowledgements: Health Education England.
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Reports on clinical cases of orphan pathologies, as autosomal recessive type of infantile malignant osteopetrosis, have a great practical importance for scholars. Osteopetrosis may already manifest itself in utero. In early childhood, there is a classic triad of symptoms: increased bone density and fragility, severe anemia. Diagnostics and allogeneic hematopoietic stem cell transplantation at the age of up to 1 year can be cured and significantly increase life expectancy. Bone marrow transplantation is only treatment that has been proven to significantly alter course of autosomal recessive type of osteopetrosis. Inspide of successful transplantation may or-thopaedic, dental problems and their vision rarely significantly improves, however haemopoietic potential is restored and the long term prognosis is favourable. Herein we report a case of patient diagnosed with osteopetrosis and underwent allogeneic hematopoietic stem cell transplantation, with no prior determination type of mutation. Complexity of case: late diagnosis autosomal recessive type of osteopetrosis (at 3.1 years), despite characteristic early clinical manifestations, a protracted preparatory period associated with search for an unrelated donor and COVID-19 pandemic, for allogeneic-hematopoietic stem cell transplantation performed at the age of 4.3 years. In resulting, was engraftment of bone marrow transplant, with restoration hematopoietic func-tion, but with preserved neurological and physical disabilities in a form of psychomotor develop-ment retardation. Allogeneic hematopoietic stem cell transplantation led to restoration hematopoietic function of the graft in this case of late diagnosis osteopetrosis.